Caspase-12

Cat no: 251476

Supplier: ABBIOTEC

0 reviews | Write a Review Pencil

Description
Additional Information

Inactive caspase-12 (caspase-12) reduces cytokine release in response to bacterial lipopolysaccharide during infections. Caspase-12 reduces reduces activation of NF-kappa-B in response to TNF. Caspase-12 does not have protease activity. The most frequent caspase-12 variant has a stop codon instead of Arg-125, giving rise to a truncated protein (Csp12-S). The variant Arg-125 (Csp12-L) is rare, e, Xenopus/Amphibian,cept in some populations from sub-Saharan Africa. Csp12-L may increase the susceptibility to severy sepsis, and may also increase the mortality rate in sepsis patients.

Catalogue number:	251476
Reactivities:	Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	Q6U, Xenopus/Amphibian,S9
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of mouse caspase-12.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	Caspase-12; Inactive caspase-12; CASP12; CASP-12