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Caspase-12 (CASP-12, Casp12)

Caspase-12 (CASP-12, Casp12)

Cat no: C2088-59E

Supplier: United States Biological
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Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a2b2 tetramer to form the active enzyme. A newly discovered member of this family Caspase-12, is localized to the endoplasmic reticulum (ER) but not to the cytoplasm or mitochondrion. In the ER it is associated with proteins that are involved in Alzheimer disease. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Mouse spleen Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2088-59E
Reactivities: Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yanker BA, Yuan J. Nature 403: 98-103 (2000). 2. Mehemt H. Nature 403: 29-30 (2000). 3. Van de Craen M, Vandenabeele P, Declercq W, Van den Brande I, et al. FEBS Lett 403:61-69 (1997). 4. Nakagawa T and J Yuan. Cross-talk between two cysteine protease families: Activation of caspase-12 by calpain in apoptosis. JCB 150:887-894 (2000).
Additional info: Recognizes mouse Caspase-12. Species Crossreactivity: rat.

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