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Caspase 13 (CASP 13, CASP13, CASP-13, Evolutionarily Related Interleukin-1beta Converting Enzyme, ERICE)

Caspase 13 (CASP 13, CASP13, CASP-13, Evolutionarily Related Interleukin-1beta Converting Enzyme, ERICE)

Cat no: C2089-01C

Supplier: United States Biological
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Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death is finally caused by members of the caspase family of proteases and caspase activated DNases. A novel member in the caspase family was recently identified and designated ERICE (for Evolutionarily Related Interleukin-1 beta Converting Enzyme) and caspase-13 (1). Caspase-13 belongs to the ICE subfamily of caspases. Overexpression of caspase-13 induces apoptosis. Caspase-13 was activated by caspase-8, which is a key enzyme in death receptor induced apoptosis. Caspase-13 is expressed in a variety of human tissues and cell lines (1). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml. Optimal dilutions to be determined by the researcher. Positive Control: HL60 cell lysate. ~43kDa Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 3 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2089-01C
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.2% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by ammonium sulfate precipitation.
References: 1. Humke EW, Ni J, Dixit VM. ERICE, a novel FLICE-activatable caspase. J Biol Chem 1998;273:15702-7
Additional info: Recognizes human, mouse and rat Casp-13.

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