Home  >  Products  >  Caspase 3 (caspase 3, apoptosis-related cysteine peptidase, apopain,CASP-3, Caspase-3, CPP32, CPP-32, CPP32B, Cysteine Protease CPP32, SCA-1, SREBP cleavage activity 1, Yama, Yama Protein)
Caspase 3 (caspase 3, apoptosis-related cysteine peptidase, apopain,CASP-3, Caspase-3, CPP32, CPP-32, CPP32B, Cysteine Protease CPP32, SCA-1, SREBP cleavage activity 1, Yama, Yama Protein)

Caspase 3 (caspase 3, apoptosis-related cysteine peptidase, apopain,CASP-3, Caspase-3, CPP32, CPP-32, CPP32B, Cysteine Protease CPP32, SCA-1, SREBP cleavage activity 1, Yama, Yama Protein)

Cat no: C2087-04N

Supplier: United States Biological
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Caspase-3 is regarded as a control mediator of apoptosis in mammalian cells. It is processed during apoptosis from an inactive proenzyme to its active form and func- tions to cleave certain proteins. Caspase-3 is found in some epithelia, kidney, thymus, bone, tonsil, lymph node and bone marrow cells. This antibody will help detect caspase-3 in normal and uncharacterized tissues. Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilutions: Western Blot: 0.5ug/ml. Jurkat human acute T cell leukemia cell line and DA3 mouse myeloma cell line treated with Staurosporine. Immunoprecipitation: 1ug/10e6 cells. Jurkat human acute T cell leukemia cell line treated with Staurosporine. Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2087-04N
Reactivities: Human, Mouse
Hosts: Goat
Applications: Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a lyophilized powder from PBS, pH 7.4, 5% trehalose. Reconstitute with 500ul sterile PBS.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Chowdhury, I. et al. (2008) Comp. Biochem. Physiol. B 151:10. 2. Boatright, K.M. & G.S. Salvesen (2003) Curr. Opin. Cell Biol. 15:725. 3. Launay, S. et al. (2005) Oncogene 24:5137. 4. Walsh, J.G. et al. (2008) Proc. Natl. Scad. Sci. USA 105:12815. 5. Nicholson, D.W. et al. (1995) Nature 376:37. 6. Tewari, M. et al. (1995) Cell 81:801. 7. Fernandes-Alnemri, T. et al. (1994) J. Biol. Chem. 269:30761. 8. Milisav, I. et al. (2009) Apoptosis 14:1070. 9. Han, Z. et al. (1997) J. Biol. Chem. 272:13432. 10. Rossig, L. et al. (1999) J. Biol. Chem. 274:6823. 11. Rank, K.B. et al. (2001) Protein Expr. Purif. 22:258. 12. Atkinson, E.A. et al. (1998) J. Biol. Chem. 273:21261. 13. Cohen, G.M. (1997) Biochem. J. 326:1.
Additional info: Recognizes human Caspase-3. Species Crossreactivity: mouse

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