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Caspase-3a, p17, NT (Caspase 3, Apoptosis-related Cysteine Protease A, Caspase-3, casp3a, casp3)

Caspase-3a, p17, NT (Caspase 3, Apoptosis-related Cysteine Protease A, Caspase-3, casp3a, casp3)

Cat no: C2087-02B

Supplier: United States Biological
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Caspase-3 is ubiquitously expressed, and like other caspases, is synthesized as an inactive proenzyme. Upon activation, Caspase-3 is cleaved at Asp28-Ser29 and Asp175-Ser176, thereby generating two subunits of 17kD (p17) and 12kD (p12), respectively. Recent studies have implicated that Caspase-3 is associated with the induction of apoptosis. Activation of Caspase-3 occurs in response to variety of apoptotic inducers, including Fas mediated apoptosis. In zebrafish model, the apoptosis process was also companied by the activation of caspase-3, evidenced by the high levels of activated caspase-3 throughout the cells of the blastodisc and in the cytoplasm of the yolk cell detected by immunohistochemistry. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:5000-1:20,000 Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Control Peptide: C2087-02P Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2087-02B
Reactivities: Zebrafish/Fish
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 250ul
Form: Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.1% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Nicholson, D. W., et al. (1995) Nature. 376, 37-43. 2. Schlegel, J., et al. (1996) J. Biol. Chem. 271, 1841-1844. 3. Slee, E. A., et al. (1996) Biochem. J. 315, 21-24. 4. Jacobson, M. Det al. (1996) J. Cell Biol. 133, 1041-1051. 5. Eimon, P.M., et al. (2006) Cell Death Differ. 13(10): 1619-1630.
Additional info: Recognizes zebrafish Caspase-3a.

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