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Caspase 4, NT

Cat no: C2087-24A2


Supplier: United States Biological
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Caspase-4, a member of the Caspase-1 subfamily of cysteine proteases, exists as an inactive pro-enzyme which undergoes proteolytic cleavage of its p30 precursor form, into smaller p20 and p10 subunits. The cellular localisation of Caspase-4 on the Endoplasmic Reticulum (ER) membrane, has resulted in this protein becoming a focus of studies in which dysfunction or stress to the ER membrane is implicated, such as Alzheimer
Catalogue number: C2087-24A2
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide
P type: Pab
Isotype: IgG
Purity: Purified by Immunoaffinity chromatography
References: 1. Martinon F. and Tschopp J. (2004) Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 117:561-574. 2. Kuida K., Lippke J.A., Ku G., et al. (1995) Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science 267:2000-2003. 3. Gracie J.A., Robertson S.E. and McInnes I.B. (2003) Interleukin-18. J. Leukoc. Biol. 73:213-224. 4. Kamens J., Paskind M., Hugunin M. et al. (1995) Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases. J. Biol. Chem. 270:15250-6. 5. Hitomi J., Katayama T., Eguchi Y. et al. (2004) Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death. J. Cell Biol. 165:347-356.
Additional info: Recognizes human Caspase-4. Depending on cell lines or tissues used, other cleavage products may be observed. Species Crossreactivity: mouse

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