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Caspase-6, NT (CASP-6, Apoptotic protease Mch-2, CASP6, MCH2)

Caspase-6, NT (CASP-6, Apoptotic protease Mch-2, CASP6, MCH2)

Cat no: C2087-27V

Supplier: United States Biological
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Members of the inflammatory caspase subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-6 is an executioner caspase that was identified based on its homology with human caspases 2 and 3 as well as the C. elegans cell death protein CED-3. It possesses two isoforms, of which only the longer form possesses protease activity. Caspase-6 is highly expressed in adult brains and may play a role in several neuronal pathologies. Applications: Suitable for use in ELISA, Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml Immunocytochemistry: 2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2087-27V
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Immunocytochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Zhivotovsky, B. et al. Biochim Biophys Res Comm 331, 859 (2005). 2. Martinon, F. et al. Cell 117, 561 (2004). 3. LeBlanc, A. et al. J Biol Chem 274, 23426 (1999). 4. Wolf, BB. et al. J Biol Chem 274, 20049 (1999). 5. Fernandes-Alnemri, T. et al. Cancer Res 55, 2737 (1995).
Additional info: Recognizes human Caspase-6.

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