Caspase-8 Antibody

Cat no: 250576

Supplier: ABBIOTEC

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Description
Additional Information

Caspase-8 is the most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Caspase-8 binding to the adapter molecule FADD recruits the comple, Xenopus/Amphibian, to either receptor. The resulting aggregate called death-inducing signaling comple, Xenopus/Amphibian, (DISC) triggers caspase-8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. The enzyme then cleaves and activates caspase-3, caspase-4, caspase-6, caspase-7, caspase-9 and caspase-10. Granzyme B and CPP32 cleave caspase-8 at Asp 315 and Asp 330 respectively to generate the two active subunits.

Catalogue number:	250576
Reactivities:	Human, Mouse, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	Q14790
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of rodent Caspase-8.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	Caspase-8; CASP-8; ICE-like apoptotic protease 5; MORT1-assiociated CED-3 homolog; MACH; FADD-homologous ICE/CED-3-like protease; FADD-like ICE; FLICE; Apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; CASP8; MCH5