Caspase-8 Antibody

Cat no: 252204

Supplier: ABBIOTEC

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Description
Additional Information

Caspase-8 is the most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Caspase-8 forms an aggregate with FADD called death-inducing signaling comple, Xenopus/Amphibian, (DISC). DISC performs caspase-8 proteolytic activation. The active dimeric enzyme is liberated from the DISC and free to activate downstream apoptotic proteases. Defects in caspase-8 are the cause of caspase-8 deficiency (CASP8D). CASP8D is a disorder resembling autoimmune lymphoproliferative syndrome (ALPS). It is characterized by lymphadenopathy, splenomegaly, and defective CD95-induced apoptosis of peripheral blood lymphocytes (PBLs).

Catalogue number:	252204
Reactivities:	Human
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	Q14790
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human caspase-8.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 2% BSA with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	Caspase-8; CASP-8; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; MACH; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; FLICE; Apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; CASP8; MCH5