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Caspase 8 (FLICE, MASH, Mch5) (Biotin)

Caspase 8 (FLICE, MASH, Mch5) (Biotin)

Cat no: C2087-32K

Supplier: United States Biological
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Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a2b2 tetramer to form the active enzyme. Caspase-8 (FLICE) forms a direct link between the activation of CD95 and the caspase pathway. Overexpression of Caspase-8 induces apoptosis, which can be blocked by inhibitors specific for the ICE family. Positive Control: Jurkat Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2087-32K
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Western Blot
Conjugates: Biotin
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Serum
Alternative names: CED 3, FADD homologous ICE/CED 3 like protease, FADD Homologous ICE/CED3 Like Protease, CAP4, FADD Like ICE, ICE like apoptotic protease 5, MACH, MGC78473, MORT1 associated CED 3 homolog, MORT1 associated CED3 homolog
Additional info: This antibody can be used for detection of pro-form of Caspase-8. Species Crossreactivity: Human

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