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Caspase 8 (FLICE, MASH, Mch5)

Caspase 8 (FLICE, MASH, Mch5)

Cat no: C2087-30K

Supplier: United States Biological
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Cellular Localization: Cytoplasmic Positive Control: Jurkat cell lysate.Tonsil tissue sections. Applications: Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry (paraffin-embedded sections). Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2087-30K
Reactivities: Human
Hosts: Mouse
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 500ul
Form: 10mM PBS, pH7.4, 0.2%BSA, 0.09% sodium azide
P type: Mab
Isotype: IgG1,k
Purity: Purified by Protein G affinity chromatography.
Alternative names: CED 3, FADD homologous ICE/CED 3 like protease, FADD Homologous ICE/CED3 Like Protease, CAP4, FADD Like ICE, ICE like apoptotic protease 5, MACH, MGC78473, MORT1 associated CED 3 homolog, MORT1 associated CED3 homolog
References: Martin DA et al. Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHalpha1) death signal. J Biol Chem 273:4345-9 (1998). Hu S et al. I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis. J Biol Chem 272:17255-7 (1997). Muzio M et al. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex. Cell 85:817-27 (1996).
Additional info: Species Crossreactivity: Crossreacts with Human.

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