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Caspase 8l2, ID (Casp8l2, Casp8b, Caspase 8b)

Caspase 8l2, ID (Casp8l2, Casp8b, Caspase 8b)

Cat no: C2087-43G

Supplier: United States Biological
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Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-8 is an initiator caspase that was identified as a member of the Fas/APO-1 death-inducing signaling complex. The adaptor molecule FADD couples procaspase-8 to the Fas receptor death domain; subsequent oligomerization promotes procaspase-8 autoactivation. FLIP, a catalytically inactive caspase-8- like molecule inhibits these interactions and thus can inhibit apoptosis. Genes with homology to mammalian apoptosis regulators was also identified in zebrafish. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:5000-1:20,000 Optimal dilutions to be determined by the researcher. Control Peptide: C2087-43P Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2087-43G
Reactivities: Zebrafish/Fish
Hosts: Rabbit
Applications: ELISA
Size: 250ul
Form: Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Martinon, F. et al. Cell 117, 561 (2004). 2. Zhivotovsky, B. et al. Biochim. Biophys. Res. Comm. 331, 859 (2005). 3. Wolf, BB. et al. J. Biol. Chem. 274, 20049 (1999). 4. Muzio, M. et al. Cell 85, 817 (1996). 5. Ashkenazi, A. et al. Science 281, 1305 (1998). 6. Irmler, M. et al. Nature 388, 190 (1997). 7. Inohara, N. and Nu
Additional info: Recognizes zebrafish Caspase 8l2.

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