Home  >  Products  >  Caspase-9, p37 (CASP9, Caspase 9, Caspase-9, CASP-9, ICE-like Apoptotic Protease 6, ICE-LAP6, Apoptotic Protease Mch-6, Apoptotic Protease-activating Factor 3, APAF-3, MCH6)
Caspase-9, p37 (CASP9, Caspase 9, Caspase-9, CASP-9, ICE-like Apoptotic Protease 6, ICE-LAP6, Apoptotic Protease Mch-6, Apoptotic Protease-activating Factor 3, APAF-3, MCH6)

Caspase-9, p37 (CASP9, Caspase 9, Caspase-9, CASP-9, ICE-like Apoptotic Protease 6, ICE-LAP6, Apoptotic Protease Mch-6, Apoptotic Protease-activating Factor 3, APAF-3, MCH6)

Cat no: C2088-06B

Supplier: United States Biological
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Caspase-9 is a member of the CED-3 subfamily, bearing high similarity to caspase-3. Procaspase-9 contains a long N-terminal putative prodomain with high similarity to the prodomains of CED-3 and caspase-2. It contains two potential processing sites between its large and small subunits. It was demonstrated that both caspase-3 and granzyme B activated pro-caspase-9, although to differently sized products. By cleavage of caspase-3, it generates two products of molecular masses C37 kD (p37) and C10 kD (p10). The ability of caspase-3 to activate pro-caspase-9 suggests that the latter is downstream of caspase-3 and, once activated, caspase-9 can initiate a caspase cascade involving the downstream executioner caspases-3, -6, and -7. The involvement of caspase-9 in the process of apoptosis in zebrafish model was also investigated. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:5000-1:20,000 Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Control Peptide: C2088-06N Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2088-06B
Reactivities: Zebrafish/Fish
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 250ul
Form: Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.1% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Srinivasula, S. M., et al. (1996) J. Biol. Chem. 271, 27099-27106. 2. Duan, H., et al. (1996) J. Biol. Chem. 271, 16720-16724. 3. Sidi, S., et al. (2008) Cell 133(5): 864-877. 4. Eimon, P.M., et al. (2006) Cell Death Differ. 13(10): 1619-1630. 5. Inohara, N. et al. Cell Death Differ. 7(5): 509-510.
Additional info: Recognizes zebrafish caspase-9.

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