Caspase 9, Recombinant, Human (ICE-LAP6, Mch6, Apaf 3)

Caspase-9 (also know as Ice-Lap6 and Mch6) is a member of the interleukin-1b converting enzyme (ICE) family of cysteine proteases. Similar as other caspases, caspase-9 also exists in cells as an inactive proenzyme. During the initiation of apoptosis the proenzyme is processed at aspartate residues to form active caspase-9. As one of the initiator caspases, active caspase-9 functions to trigger the activation of downstream effector caspases and further leads to disassembly of cell structures. \n\nThe active recombinant human caspase-9 was expressed in E. coli. The expressed caspase-9 spontaneously undergoes autoprocessing to yield the subunits characteristic of the native enzyme. In combination with caspase-9 activity assays, the active recombinant caspase-9 is useful in screening caspase inhibitors for pharmaceutical applications. The recombinant enzyme can also be used as a positive control in caspase-9 assays. 6x His tags are located on the N and C termini.\n\nFor a complete caspase-9 assay protocol, please refer to Caspase-9/Mch6 Fluorometric or Colorimetric Assay Kits, USBio# C2088-05, C2088-10.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts