Caspase Family Group II, Active, Recombinant (Caspases-2,3,7)

Caspase family proteases play an important role in apoptosis. Currently, the family consists of more than 10 members. Based on their extended substrate specificities, these enzymes were divided into three major groups: \nGroup I (contains caspase-1,-4,-5)\nGroup II (contains caspase-2,-3,-7)\nGroup III (contains caspase-6,-8,-9,-10). \n\nEvidences have suggested that Group I caspases are involved primarily in the production of inflammatory cytokines, while group II and III enzymes function in apoptosis as effectors and upstream activators, respectively. Active recombinant human caspases were expressed in E. coli and routinely tested for their ability to enzymatically cleave the substrate VEID-pNA (for caspase-6), IETD-pNA (for caspase-8 & -10) and LEHD-pNA (for caspase-9), respectively. \n\nHighly active recombinant human caspases were expressed in E. coli and purified. Active recombinant caspases are useful in screening caspase inhibitors, studying enzyme kinetics and regulation, determining target substrates and as a positive control in caspase activity assays. We recommend using 1 unit per assay for analyzing caspase activity.

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