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Catalase (CAT, HGNC:1516, MGC138422, MGC138424)

Catalase (CAT, HGNC:1516, MGC138422, MGC138424)

Cat no: C2096-05L

Supplier: United States Biological
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Catalase is a tetrameric hemoprotein which degrades H2O2. Human catalase is a heme-containing peroxisomal enzyme that breaks down hydrogen peroxide to water and oxygen; it is implicated in ethanol metabolism, inflammation, apoptosis, aging and cancer (1). Although catalase is a major intracellular antioxidant, the expression of the human catalase gene appears to be limited in the airway epithelium, making these cells vulnerable to oxidant stress (2). Transgenic mice that overexpress human catalase localized to the peroxisome, the nucleus, or mitochondria showed cardiac pathology and cataract development were delayed, oxidative damage was reduced, H2O2 production and H2O2-induced aconitase inactivation were attenuated, and the development of mitochondrial deletions was reduced (3). Applications: Suitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Immunoprecipitation: 1:10 Immunohistochemistry: 1:100-1:250 Immunocytochemistry: 1:50-1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2096-05L
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: CAT, catalase, HGNC:1516, MGC138422, MGC138424
References: 1. Yoo JH, et al. J Clin Invest. 93(1):297-302, 1994. 2. Putnam CD, et al. J Mol Biol. 296(1): 295-309, 2000. 3. Schriner SE, et al. Science 308(5730):1909-11, 2005
Additional info: Recognizes human Catalase. Species Crossreactivity: Mouse and rat.

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