Home  >  Products  >  Catenin, alpha (Catenin alpha-1, CTNNA1, Alpha E-catenin, CAP102, Cadherin-associated Protein, FLJ36832, FLJ52416, Renal Carcinoma Antigen NY-REN-13)
Catenin, alpha (Catenin alpha-1, CTNNA1, Alpha E-catenin, CAP102, Cadherin-associated Protein, FLJ36832, FLJ52416, Renal Carcinoma Antigen NY-REN-13)

Catenin, alpha (Catenin alpha-1, CTNNA1, Alpha E-catenin, CAP102, Cadherin-associated Protein, FLJ36832, FLJ52416, Renal Carcinoma Antigen NY-REN-13)

Cat no: C2069-40P

Supplier: United States Biological
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E-cadherin is a transmembrane glycoprotein responsible for physical connection of epithelial cells through Ca(2+)-binding regions in its extracellular domain. E-cadherin-mediated cell-cell adhesion is effected by 3 cytoplasmic proteins known as catenins alpha, beta, and gamma. These catenins are thought to work as connectors that anchor the E-cadherin to the cytoskeletal actin bundle through the cadherin cytoplasmic domain. Alpha-catenin, a cadherin-associated protein, links cadherin/beta-catenin and cadherin/plakoglobin complexes to the actin cytoskeleton.Thus it is required for the function of cadherins, cell adhesion molecules.The gene encodes 906 amino acids and is mapped to 5q31. Pathological role of alpha-catenin has been observed in human myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). It is expressed ubiquitously in normal tissues. Alternatively spliced transcript variants encoding two isoforms have been identified. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 1:50-1:100 Western Blot: 1:100-750 Optimal dilutions to be determined by the researcher. Positive Control: Human lung cell line Cellular Localization: Cytoplasmic and cell membrane Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2069-40P
Reactivities: Human, Mouse, Xenopus/Amphibian
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 500ul
Form: Supplied as a liquid in 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Serum
Alternative names: Catenin (Cadherin-associated Protein), alpha 1, 102kDa
References: 1. Koslov et al. J Biol Chem 272 (43): 27301, 1997. 2. Rimm et al. Lab Invest 72 (5): 590, 1995. 3. Hazan et al. J Biol Chem 272 (51): 32448, 1997. 4. Taniguchi et al. Int J Mol Med 16:1003, 2005.
Additional info: Recognizes human Alpha-Catenin. Species Crossreactivity: mouse and xenopus.

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