Home  >  Products  >  Catenin, alpha (Catenin alpha-1, CTNNA1, Alpha E-catenin, CAP102, Cadherin-associated Protein, FLJ36832, FLJ52416, Renal Carcinoma Antigen NY-REN-13)
Catenin, alpha (Catenin alpha-1, CTNNA1, Alpha E-catenin, CAP102, Cadherin-associated Protein, FLJ36832, FLJ52416, Renal Carcinoma Antigen NY-REN-13)

Catenin, alpha (Catenin alpha-1, CTNNA1, Alpha E-catenin, CAP102, Cadherin-associated Protein, FLJ36832, FLJ52416, Renal Carcinoma Antigen NY-REN-13)

Cat no: C2069-40Q

Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
E-cadherin is a transmembrane glycoprotein responsible for physical connection of epithelial cells through Ca(2+)-binding regions in its extracellular domain. E-cadherin-mediated cell-cell adhesion is effected by 3 cytoplasmic proteins known as catenins alpha, beta, and gamma. These catenins are thought to work as connectors that anchor the E-cadherin to the cytoskeletal actin bundle through the cadherin cytoplasmic domain. a-catenin, a cadherin-associated protein, links cadherin/beta-catenin and cadherin/plakoglobin complexes to the actin cytoskeleton.Thus it is required for the function of cadherins, cell adhesion molecules.The gene for a-catenin is mapped to 5q31. Pathological role of a-catenin has been observed in human myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). It is expressed ubiquitously in normal tissues. Alternatively spliced transcript variants encoding two isoforms have been identified. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2069-40Q
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: Catenin (Cadherin-associated Protein), alpha 1, 102kDa
References: 1. Koslov, ER. et al. J. Biol. Chem. 272:27301-27306 (1997). 2. Rimm, EB. et al. Lab. Invest. 72:590-603 (1995). 3. Taniguchi et al. Int. J. Mol. Med. 16:1003-1008 (2005).
Additional info: Recognizes human a-catenin. Species crossreactivity: mouse.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave