Home  >  Products  >  Catenin alpha1 (alpha-1 Catenin, CTNNA1, Catenin (Cadherin-associated Protein) alpha 1 102kDa, Catenin alpha, alpha-Catenin, alpha-E-Catenin, alphaE-Catenin, CAP102, FLJ36832, FLJ52416, HGNC:2509, NY-REN-13 Antigen, Renal Carcinoma Antigen NY-REN-13)
Catenin alpha1 (alpha-1 Catenin, CTNNA1, Catenin (Cadherin-associated Protein) alpha 1 102kDa, Catenin alpha, alpha-Catenin, alpha-E-Catenin, alphaE-Catenin, CAP102, FLJ36832, FLJ52416, HGNC:2509, NY-REN-13 Antigen, Renal Carcinoma Antigen NY-REN-13)

Catenin alpha1 (alpha-1 Catenin, CTNNA1, Catenin (Cadherin-associated Protein) alpha 1 102kDa, Catenin alpha, alpha-Catenin, alpha-E-Catenin, alphaE-Catenin, CAP102, FLJ36832, FLJ52416, HGNC:2509, NY-REN-13 Antigen, Renal Carcinoma Antigen NY-REN-13)

Cat no: C2069-40J

Supplier: United States Biological
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Alpha-catenin belongs together with beta and gamma-catenin to the catenin family. Catenins comprise a large family of Ca2+-dependent, homotypic cell-cell adhesion molecules that play important roles in development, epithelial cell polarity and tumor progression. Cadherins are single pass, type I transmembrane proteins that are localized in the adherens junction. To be fully functional, the cadherin cytoplasmic domain must be linked to the actin cytoskeleton through a group of proteins termed catenins: alpha-catenin, beta-catenin and plakoglobin. Alpha catenin interacts with the cadherin indirectly via interactions with beta-catenin or plakoglobin. Applications: Suitable for use in Immunofluorescence, Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Immunofluorescence: 1:10 Western Blot: 1:10 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2069-40J
Reactivities: Human
Hosts: Mouse
Applications: Immunofluorescence, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
References: 1. Nieman, M et al; Mechanism of extracellular domain-deleted dominant negative cadherins. J. Cell Science 1999, 112: 1621 2) Johnson, K et al; P- and E-cadherin are in separate complexes in cells expressing both cadherins. Exp Cell Res 1993, 207: 252.
Additional info: Recognizes human alpha-catenin.

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