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Catenin, beta 1,2, Phosphorylated (Ser674) (Beta-catenin 2, ctnnb2, zgc:65770)

Catenin, beta 1,2, Phosphorylated (Ser674) (Beta-catenin 2, ctnnb2, zgc:65770)

Cat no: C2069-53C

Supplier: United States Biological
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Catenin-beta plays a central role in cell adhesion, bridging between cadherins and actin cytoskeleton. These activities are regulated through its differential interaction with several molecular partners, including cell- cell adherens junctions molecules, components of its degradation complex, and transcription factors. Catenin-beta is composed of three domains: a central armadillo repeat domain and two N- and C-terminal tails. Catenin-beta can be phosphorylated by serine-threonine kinase, such as GSK-3. The phosphorylated catenin-beta affects the protein association of catenin-beta to E-cadherin and alpha-cateinin that occurs in the cell. This process can be reversed by dephosphorylation of catenin-beta. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:5000-1:20,000 Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Control Peptide: C2069-53C1 Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2069-53C
Reactivities: Zebrafish/Fish
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 250ul
Form: Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Dale TC. (1998) Biochem J. 329: 209-23. 2. J. Cell Science 115: 2771-2780. 3. Giannini, A et al (2000) J. Biol. Chem. 275(29): 21883-21888. 4. Thilo, H et al, (2002) J. Bio. Chem. 277 (26): 2330-2335). 5. Castano J et al (2002) J. Biol. Chem. 277(35): 31541.
Additional info: Recognizes zebrafish Catenin-beta 1, 2 when Phosphorylated at Ser674.

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