Catenin, beta

Cat no: C2069-49L

Supplier: United States Biological

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Applications: Suitable for use in Immunofluorescence, Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilution: Immunofluorescence: 1:1000 Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Cellular Localization: Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Positive Control: MDBK cells Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Catalogue number:	C2069-49L
Reactivities:	Human, Bovine, Canine, Chicken/Bird
Hosts:	Mouse
Applications:	Immunocytochemistry, Immunofluorescence, Western Blot
Size:	100ul
Form:	Ascitic fluid with 0.1% sodium azide
P type:	Mab
Isotype:	IgG1
Purity:	Ascites
Alternative names:	Cadherin associated protein, CATNB, CTNNB, CTNNB1
References:	Reynolds AB et al. Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes. Mol Cell Biol 14:8333-42 (1994). Tsukita S et al. Submembranous junctional plaque proteins include potential tumor suppressor molecules. J Cell Biol 123:1049-53 (1993). Johnson KR et al. P- and E-cadherin are in separate complexes in cells expressing both cadherins. Exp Cell Res 207:252-60 (1993). Edelman GM & Crossin KL Cell adhesion molecules: implications for a molecular histology. Annu Rev Biochem 60:155-90 (1991). Takeichi M Cadherin cell adhesion receptors as a morphogenetic regulator. Science 251:1451-5 (1991). Nagafuchi A & Takeichi M Cell binding function of E-cadherin is regulated by the cytoplasmic domain. EMBO J 7:3679-84 (1988).
Additional info:	Recognizes chicken beta-catenin (Mr: 94kD). Does not crossreact with plakoglobin. Species Crossreactivity: bovine, canine and human.

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Catenin, beta

Cat no: C2069-49L

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