Catenin-(beta) (I35) pAb

Cat no: BS1041

Supplier: Bioworld Technology, Inc.

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Description
Additional Information

(beta)-Catenin is a key downstream effector in the Wnt signaling pathway. It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis. CK1 phosphorylates (beta)-catenin at Ser45. This phosphorylation event primes (beta)-catenin for subsequent phosphorylation by GSK-3(beta). GSK-3(beta) destabilizes (beta)-catenin by phosphorylating it at Ser33, Ser37, and Thr41. Mutations at these sites result in the stabilization of (beta)-catenin protein levels and have been found in many tumor cell lines.

Catalogue number:	BS1041
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Western Blot
Size:	100ug/100ul
Swiss prot:	P35222
Dilutions:	WB: 1:500~1:1000
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Synthetic peptide, corresponding to amino acids N-terminus of Human Catenin-(beta).
Species:	Catenin-(beta) (I35) pAb detects endogenous levels of Catenin-(beta) protein.
Molecular weight:	~ 92 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	Catenin (beta); Catenin(beta); Catenin beta-1; Beta-catenin; CTNNB1; CTNNB; ORF Names: OK/SW-cl.35; PRO2286
Additional info:	For research use only, not for use in diagnostic procedure.

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Catenin-(beta) (I35) pAb

Cat no: BS1041

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