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Catenin beta, Phosphorylated (Ser675) (CTNNB1, Catenin beta-1, Beta-catenin, CTNNB, OK/SW-cl.35, PRO2286)

Catenin beta, Phosphorylated (Ser675) (CTNNB1, Catenin beta-1, Beta-catenin, CTNNB, OK/SW-cl.35, PRO2286)

Cat no: C2096-60J

Supplier: United States Biological
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Catenin-b plays a central role in cell adhesion, bridging between cadherins and actin cytoskeleton. These activities are regulated through its differential interaction with several molecular partners, including cell- cell adherens junction (AJ) molecules, components of its degradation complex, and transcription factors. Beta-Catenin is composed of three domains: a central armadillo repeat domain and two N- and C-terminal tails. Beta-catenin can be phosphorylated by serine-threonine kinase, such as GSK-3. The phosphorylated beta-catenin affects the protein association of beta-catenin to E-cadherin and alpha-cateinin that occurs in the cell. This process can be reversed by dephosphorylation of beta-catenin. Applications: Suitable for use in Immunohistochemistry and Western Blot. Other applications not tested. Recommended Dilution: Immunohistochemistry: 1-2ug/ml Western Blot: 0.5-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2096-60J
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Castano, J. et al. J Biol Chem 277, 31541 (2002). 2. J Cell Science 115, 2771 3. Thilo, H et al. J Bio Chem 277, 2330 (2002). 4. Giannini, A. et al. J Biol Chem 275, 21883 (2000). 5. Dale, T. et al. Biochem J 329, 209 (1998).
Additional info: Recognizes human beta-catenin when phosphorylated at Ser675. Species Crossreactivity: mouse.

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