Catenin, delta 1 (CTNND1, Cadherin-Associated Protein delta 1, Cadherin-associated Src Substrate, CAS, p120 Catenin, p120(ctn), p120(cas), KIAA0384)

Catenins are proteins associated with complexes that contain cadherin cell adhesion molecules. Delta-1-catenin is a member of the p120 Catenin subfamily and is a structural protein involved in neuronal development. It interacts with Actin, Cortactin and Src Kinases to promote neurite elongation or branching, depending upon its phosphorylation state. Like beta-catenin and gamma-catenin, delta-catenins appear to interact with presenilins. These catenin-presenilin interactions can impact cadherin function and regulation of cell-to-cell adhesion. While beta-catenin acts as a transcription regulatory protein in the Wnt/TCF pathway, delta-catenin has been implicated as a regulator of the NF-kB transcription factor.\n\nApplications: \nSuitable for use in ELISA, Western Blot, Immunoprecipitation, Immunofluorescence and Immunocytochemistry. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1:10,000 using whole cell extract of cultured chicken fibroblasts. Detects a band at ~120kD and an possible additional weak doublet of ~200kD.\nImmunofluorescence: 1:100 using cultured Madin Darby canine kidney (MDCK) epithelial cells.\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

C2069-54K

Size

100ul

Applications

ELISA, ICC, IF, IP, WB

Hosts

Mouse

Reactivities

Hum, Mouse, Rat, Bov, Can, Ch/Bird

Form

Supplied as a liquid, 15mM sodium azide.

P Type

Mab

Purity

Supernatant

Isotype

IgG1

References

1. Mo YY & Reynolds AB Identification of murine p120 isoforms and heterogeneous expression of p120cas isoforms in human tumor cell lines. Cancer Res 56:2633-40 (1996). 2. Tsukita S et al. Submembranous junctional plaque proteins include potential tumor suppressor molecules. J Cell Biol 123:1049-53 (1993). 3. Edelman GM & Crossin KL Cell adhesion molecules: implications for a molecular histology. Annu Rev Biochem 60:155-90 (1991). 4. Takeichi M Cadherin cell adhesion receptors as a morphogenetic regulator. Science 251:1451-5 (1991).

Additional Info

Recognizes mouse delta 1 Catenin. Specifically reacts with the N-terminal region. Reacts with isoforms 1 and 2 but does not react with isoforms 3 or 4. Species Crossreactivity: rat, bovine, chicken, canine, human .

Alternative Names

CTNND1, Cadherin-Associated Protein delta 1, Cadherin-associated Src Substrate, CAS, p120 Catenin, p120(ctn), p120(cas), KIAA0384