Catenin, p120, phosphorylated (Threonine 310)

Cat no: C2069-39G

Supplier: United States Biological

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Catenins are proteins that are linked to the cytoplasmic domain of transmembrane cadherins. p120 Catenin is one member of this Armadillo gene family of junctional plaque proteins (1-3). The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be important for cadherins cell-adhesion properties. Recently it became clear that some catenins also mediate nuclear signaling (1). p120 Catenin is implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Applications: Suitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry. Other applications not tested. Recommended Dilution: Wesytern Blot: 1:500-1:1000 Immunohistochemistry: 1:100-1:250 Immunoprecipitation: 1:10 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.

Catalogue number:	C2069-39G
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Immunohistochemistry, Immunoprecipitation, Western Blot
Size:	100ul
Form:	Supplied as a liquid in 50 mM Tris-Glycine, pH 7.4, 0.15 M sodium chloride, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
P type:	Mab
Isotype:	IgG
Purity:	Supernatant
Alternative names:	p120 catenin, p120(ctn), Cadherin-associated Src substrate, CAS, p120(cas)
References:	1. Keirsebilck, A., et al. Genomics 50: 129, 1998 2. Aho, S., et al. J Cell Sci. 115: 1391, 2002 3. van Hengel, J., et al. Proc Natl Acad Sci U S A. 96: 7980, 1999
Additional info:	Recognizes human p120 Catenin phosphorylated on Threonine 310. Species crossreactivity: mouse and rat.

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Catenin, p120, phosphorylated (Threonine 310)

Cat no: C2069-39G

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