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Cathepsin B

Cathepsin B

Cat no: C2097-02B

Supplier: United States Biological
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Cathepsin B is a cysteine endopeptidase which is synthesized as a 40kD inactive glycoprotein which is processed into the mature form. Cathepsin B is widely expressed by various tissues. Applications: Suitable for use in Immunohistochemistry (paraffin-embedded sections). Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2097-02B
Reactivities: Human
Hosts: Mouse
Applications: Immunohistochemistry
Size: 500ul
Form: PBS with 0.09% sodium azide
P type: Mab
Isotype: IgG2b
Purity: Tissue culture supernatant
References: This product has been used in:Ravikumar B et al. Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy. Hum Mol Genet 12:985-94 (2003). Strojnik T et al. Cathepsin B immunohistochemical staining in tumor and endothelial cells is a new prognostic factor for survival in patients with brain tumors. Clin Cancer Res 5:559-67 (1999).
Additional info: This antibody is specific for Cathepsin B, a lysosomal protease expressed in a wide range of tissues, including liver, skeletal muscle, and heart. Species Crossreactivity: Crossreacts with Human.

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