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Cathepsin D (CatD, CLN10, CPSD, CTSD, Lysosomal aspartyl peptidase, MGC2311 )

Cathepsin D (CatD, CLN10, CPSD, CTSD, Lysosomal aspartyl peptidase, MGC2311 )

Cat no: C2097-24D

Supplier: United States Biological
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Cathepsin D has been reported to be involved in malignant tumor progression and with prognosis of various human cancers. Applications: Suitable for use in Immunohistochemistry (paraffin-embedded sections). Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin-embedded sections): 1:75-1:200 using ABC method. An incubation period of 30 mins. at RT is suggested. Optimal dilutions to be determined by the researcher. Cellular Localization: Cytoplasmic Positive Control: Breast Carcinoma Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2097-24D
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 250ul
Form: Supplied as a liquid in PBS containing BSA and sodium azide
P type: Pab
Isotype: IgG
Purity: Purified
Alternative names: CatD, CLN10, CPSD, CTSD, Lysosomal aspartyl peptidase, MGC2311
References: 1. Henry JA et al. Prognostic significance of the estrogen-regulated protein, cathepsin D, in breast cancer. An immunohistochemical study. Cancer 65:265-71 (1990). 2. Garcia M et al. Immunohistochemical distribution of the 52-kDa protein in mammary tumors: a marker associated with cell proliferation rather than with hormone responsiveness. J Steroid Biochem 27:439-45 (1987)
Additional info: Recognizes human Cathepsin D. Reacts with the zymogen as well as the activated form of cathepsin D. It stains fibroblasts and macrophages strongly but stains weakly with the myoepithelial cells of breast. It also stains sweat ducts and glands in the skin, islets cells and granules of pancreatic acini.

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