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Cathepsin D (CatD, CLN10, CPSD, CTSD, Lysosomal aspartyl peptidase, MGC2311)

Cathepsin D (CatD, CLN10, CPSD, CTSD, Lysosomal aspartyl peptidase, MGC2311)

Cat no: C2097-26B

Supplier: United States Biological
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Cathepsin D is a ubiquitously expressed lysosomal protease that is involved in proteolytic degradation, cell invasion, and apoptosis (1). It is suspected to play important roles in protein catabolism, antigen processing, degenerative diseases, and breast cancer progression (2). Cathepsin D is induced by estrogens in mammary cancer cells where its concentration is correlated with a higher risk of metastasis (3). It is possibly involved in Alzheimer's disease-related neurodegeneration through cleavage of amyloid precursor protein into amyloidogenic components (4). Preprocathepsin D (43kD) is cleaved and glycosylated to form procathepsin D (46kD), and then further cleaved, forming light and a heavy chains (15kDa and 28kDa, respectively) (5). Applications: Suitable for use in Western Blot, Immunohistochemistry, Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:1000
Catalogue number: C2097-26B
Reactivities: Human
Hosts: Rabbit
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Steinfeld R, et al. Am J Hum Genet. 78(6):988-98, 2006. 2. Baldwin ET, et al. Proc Natl Acad Sci U S A. 90(14):6796-800, 1993. 3. Augereau P, et al. Mol Endocrinol. 8(6):693-703, 1994. 4. Papassotiropoulos A, et al. Ann Neurol. 47(3):399-403,2000.5. Erickson AH, et al. J Biol Chem. 256(21):11224-31, 1981.
Additional info: Recognizes human Cathepsin D.

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