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Cathepsin D (Cathepsin-D, CatD, CLN10, CPSD, CTSD, Lysosomal Aspartyl Peptidase, MGC2311)

Cathepsin D (Cathepsin-D, CatD, CLN10, CPSD, CTSD, Lysosomal Aspartyl Peptidase, MGC2311)

Cat no: C2097-24G

Supplier: United States Biological
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Cathepsin D is a ubiquitously expressed lysosomal protease that is involved in proteolytic degradation, cell invasion, and apoptosis (1). It is suspected to play important roles in protein catabolism, antigen processing, degenerative diseases, and breast cancer progression (2). Cathepsin D is induced by estrogens in mammary cancer cells where its concentration is correlated with a higher risk of metastasis (3). It is possibly involved in Alzheimer's disease-related neurodegeneration through cleavage of amyloid precursor protein into amyloidogenic components (4). Preprocathepsin D (43kDa) is cleaved and glycosylated to form procathepsin D (46kDa), and then further cleaved, forming light and a heavy chains (15kDa and 28kDa, respectively) (5). Applications: Suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:2000-1:10,000 Immunohistochemistry: 1:250-1:500 Immunocytochemistry: 1:250-1:500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: C2097-24G
Reactivities: Human
Hosts: Rabbit
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% glycerol, 0.01% sodium azide and 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Steinfeld R, et al. Am J Hum Genet. 78(6):988-98, 2006 2. Baldwin ET, et al. Proc Natl Acad Sci U S A. 90(14):6796-800, 1993 3. Augereau P, et al. Mol Endocrinol. 8(6):693-703, 1994 4. Papassotiropoulos A, et al. Ann Neurol. 47(3):399-403,2000 5. Shewale JG, et al. PNAS 81(12): 3703-3707, 1984-06
Additional info: Recognizes human Cathepsin D.

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