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Cathepsin H, Recombinant, Human, aa23-335, His-Tag (CTSH, Cathepsin H Mini Chain, Cathepsin H Heavy Chain, Cathepsin H Light Chain, CPSB)

Cathepsin H, Recombinant, Human, aa23-335, His-Tag (CTSH, Cathepsin H Mini Chain, Cathepsin H Heavy Chain, Cathepsin H Light Chain, CPSB)

Cat no: C2097-62

Supplier: United States Biological
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Cathepsin H is a lysosomal cysteine protease of the papain family. It is synthesized as a precursor protein that is proteolytically processed to a mature form consisting of a light chain, a heavy chain, and a minichain. Cathepsin H is the only known monoaminopeptidase in the papain family. Cathepsin H is primarily an aminopeptidase, but also functions as an endopeptidase. Cathepsin H is potently inhibited by cystatins A, B, and C and by ovocystatin. Cathepsin H expression is altered in disease states such as prostate and colorectal cancers. Source: Recombinant corresponding to aa23-335 from human Cathepsin H fused to 10-His-tag at C-terminal expressed in CHO cell line. Molecular Weight: ~37kD Biological Activity: Measured by its ability to cleave the fluorogenic peptide substrate, Arg7amido4methylcoumarin (RAMC). Specific Activity: >750 pmol/min/ug, as measured under the described conditions. Endotoxin: ~1EU/1ug (LAL) Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70 degrees C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2097-62
Size: 10ug
Form: Supplied as a liquid in Tris, sodium chloride. BSA free.
Purity: ~80% (SDS-PAGE)
References: 1. Kirshke, H. (2004) in Handbook of Proteolytic Enzymes (ed. Barrett et al.) p. 1089, Academic Press, San Diego. 2. Fuchs, R. et al. (1988) Biol. Chem. HoppeSeyler 369:469. 3. Guncar, G. et al. (1998) Structure 310:113. 4. Kirschke, H. et al. (1977) Acta Biol. Med. Ger. 6:51. 5. del Re, E.C. et al. (2000) Br. J. Cancer 82:1317.

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