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Products Cathepsin L (Cathepsin L heavy chain, Cathepsin L light chain, CATL, CTSL, Major excreted protein, MEP)
| Catalogue number: | C2097-70J |
| Reactivities: | Human, Mouse, Rat |
| Hosts: | Mouse |
| Applications: | ELISA, Immunohistochemistry, Western Blot |
| Size: | 100ul |
| Form: | Supplied as a liquid, 15mM sodium azide. |
| P type: | Mab |
| Isotype: | IgG1 |
| Purity: | Ascites |
| Alternative names: | Cathepsin L heavy chain, Cathepsin L light chain, CATL, CTSL, Major excreted protein, MEP |
| References: | 1. Sivaparvathi M <i>et al.</i> Expression and immunohistochemical localization of cathepsin L during the progression of human gliomas. <i>Clin Exp Metastasis</i> <b>14</b>:27-34 (1996). <PUBMED:8521613> 2. Igdoura SA <i>et al.</i> Differential expression of cathepsins B and D in testis and epididymis of adult rats. <i>J Histochem Cytochem</i> <b>43</b>:545-57 (1995). <PUBMED:7730593> 3. Weber E <i>et al.</i> Hybridoma cells producing antibodies to cathepsin L have greatly reduced potential for tumour growth. <i>J Cancer Res Clin Oncol</i> <b>120</b>:564-7 (1994). <PUBMED:8045924> 4. Mignatti P & Rifkin DB Biology and biochemistry of proteinases in tumor invasion. <i>Physiol Rev</i> <b>73</b>:161-95 (1993). <PUBMED:8419965> 5. Heidtmann HH <i>et al.</i> Secretion of a latent, acid activatable cathepsin L precursor by human non-small cell lung cancer cell lines. <i>Oncol Res</i> <b>5</b>:441-51 (1993). <PUBMED:8054705> 5. Yamaguchi N <i>et al.</i> Characterization of a cathepsin L-like enzyme secreted from human pancreatic cancer cell line HPC-YP. <i>Cancer Res</i> <b>50</b>:658-63 (1990). <PUBMED:2297706> 6. Trabandt A <i>et al.</i> Expression of the collagenolytic and Ras-induced cysteine proteinase cathepsin L and proliferation-associated oncogenes in synovial cells of MRL/I mice and patients with rheumatoid arthritis. <i>Matrix</i> <b>10</b>:349-61 (1990). <PUBMED:2084514> 7. Bellelli A <i>et al.</i> Inhibition of tumor growth, invasion and metastasis in papain-immunized mice. <i>Invasion Metastasis</i> <b>10</b>:142-69 (1990). <PUBMED:2139872> 8. Yagel S <i>et al.</i> Suppression by cathepsin L inhibitors of the invasion of amnion membranes by murine cancer cells. <i>Cancer Res</i> <b>49</b>:3553-7 (1989). <PUBMED:2731177> 9. Denhardt DT <i>et al.</i> Cysteine proteinase cathepsin L expression correlates closely with the metastatic potential of H-ras-transformed murine fibroblasts. <i>Oncogene</i> <b>2</b>:55-9 (1987). <PUBMED:3438085> 10. Kirschke H and Barrett AJ Chemistry of lysosomal proteases in lysosomes: Their role in protein breakdown <i>Academic Press</i> <b></b>:193-239 (1981). 11. Kirschke H <i>et al.</i> Cathepsin L. A new proteinase from rat-liver lysosomes. <i>Eur J Biochem</i> <b>74</b>:293-301 (1977). <PUBMED:15835> |
| Additional info: | Recognizes native and denatured forms of human cathepsin L (25kD) and procathepsin L (42kD). Does not react with human cathepsin types B, D, H and S, procathepsins B and D, and procathepsin H, rat cathepsin B, and mouse procathepsins B and D. Species Crossreactivity: mouse procathepsin L (weak), rat cathepsin L (strong), and mink cathepsin and procathepsin L. |
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