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Caveolin 1 (CAV1, Caveolae protein, HGNC:1527, CAV, MSTP085, Cell Growth-inhibiting Protein 32, VIP21)

Caveolin 1 (CAV1, Caveolae protein, HGNC:1527, CAV, MSTP085, Cell Growth-inhibiting Protein 32, VIP21)

Cat no: C2097-91R

Supplier: United States Biological
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Caveolae are specialized domains of the plasma membrane that are implicated in the sequestration of a variety of lipid and protein molecules. It has been suggested that these important cellular organelles have a pivotal role in such diverse biochemical processes as lipid metabolism, growth regulation, signal transduction, and apoptosis. Caveolin interacts with and regulates heterotrimeric G-proteins. Currently, there are three members of the caveolin multigene family which are known to encode 21-24kD integral membrane proteins that comprise the major structural component of the caveolar membrane in vivo. Caveolin-2 protein is abundantly expressed in fibroblasts and differentiated adipocytes, smooth and skeletal muscle, and endothelial cells. The expression of caveolin-1 is similar to that of caveolin-2 while caveolin-3 expression appears to be limited to muscle tissue types. Applications: Suitable for use in Western Blot, Immunoprecipitation, Immunocytochemistry, and Immunofluorescence. Other applications not tested. Recommended Dilution: Western Blot
Catalogue number: C2097-91R
Reactivities: Human, Mouse, Rat, Canine
Hosts: Rabbit
Applications: Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS with 1 mg/ml BSA and 0.05% sodium azide
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: CAV1, Caveolae protein, HGNC:1527, CAV, MSTP085, Cell Growth-inhibiting Protein 32, VIP21
References: Schlegel A & Lisanti MP The caveolin triad: caveolae biogenesis, cholesterol trafficking, and signal transduction. Cytokine Growth Factor Rev 12:41-51 (2001). Li WP et al. Cell-specific targeting of caveolin-1 to caveolae, secretory vesicles, cytoplasm or mitochondria. J Cell Sci 114:1397-408 (2001). Ikonen E & Parton RG Caveolins and cellular cholesterol balance. Traffic 1:212-7 (2000).
Additional info: Detects caveolin-1. Species Crossreactivity: Crossreacts with human, rat, mouse, canine and hamster.

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