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Caveolin 1 (Caveolin-1, CAV 1, CAV1, CAV, BSCL3, CGL3, MSTP085, VIP21)

Caveolin 1 (Caveolin-1, CAV 1, CAV1, CAV, BSCL3, CGL3, MSTP085, VIP21)

Cat no: C2097-93N

Supplier: United States Biological
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Official Symbol- CAV1. GenBank Accession Number(s)- NP_001744.2. GeneID- 857 (Human). Caveolins are a family of integral membrane proteins which are the principal components of caveolae membranes. Cavoleae are flask-shaped plasma membrane invaginations whose exact cellular function is not yet clear. Caveolins may act as scaffolding proteins within caveolar membranes by compartmentalizing and concentrating signaling molecules. Various classes of signaling molecules, including G-protein subunits, receptor and non-receptor tyrosine kinases, endothelial nitric oxide synthase (eNOS), and small GTPases, bind Cav-1 through its 'caveolin-scaffolding domain'. Currently, three different forms of caveolins are known: caveolin-1 (or VIP21), caveolin-2 and caveolin-3 (or M-caveolin). Caveolins are proteins of about 20 Kd, they form high molecular mass homo-oligomers. Structurally they seem to have N-terminal and C-terminal hydrophilic segments and a long central transmembrane domain that probably forms a hairpin in the membrane. Both extremities are known to face the cytoplasm. Caveolae are enriched with cholesterol and Cav-1 is one of the few proteins that binds cholesterol tightly and specifically. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 4ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human respiratory epithelium and alveoli Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2097-93N
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.7, 0.1% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: Caveolin 1, Caveolae Protein, 22kDa
References: 1. FEBS Lett 1999 Apr. 448:221-30 Sequence and detailed organization of the human caveolin-1 and -2 genes located near the D7S522 locus (7q31.1). Methylation of a CpG island in the 5' promoter region of the caveolin-1 gene in human breast cancer cell lines. Engelman JA, Zhang XL, and Lisanti MP. 2. Oncogene 1999 Mar. 18:1881-90 Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines. Hurlstone AF, Reid G, Reeves JR, Fraser J, Strathdee G, Rahilly M, Parkinson EK, and Black DM. 3. Genomics 1999 Mar. 56:355-6 Human caveolin-1 and caveolin-2 are closely linked genes colocalized with WI-5336 in a region of 7q31 frequently deleted in tumors. Fra AM, Mastroianni N, Mancini M, Pasqualetto E, and Sitia R.
Additional info: Recognizes human CAV-1.

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