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Cbl (CBL, CBL2, C-CBL, RNF55, Cas-Br-M (murine) Ecotropic Retroviral Transforming Sequence, Oncogene CBL2)

Cbl (CBL, CBL2, C-CBL, RNF55, Cas-Br-M (murine) Ecotropic Retroviral Transforming Sequence, Oncogene CBL2)

Cat no: C0013-32A

Supplier: United States Biological
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The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C0013-32A
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Thien, C.B.F., et al., (2005), "C-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signaling responses", Biochem. J., 391: 153-166. 2. Weissman, A.M., et al., (2001), "Themes and variations on ubiquitylation", Nat. Rev. Mol. Cell Biol., 2: 169-178. 3. Swaminathan, G., et al., (2006), "The Cbl family of proteins: ring leaders in regulation of cell signaling", J. Cell. Physiol., 209: 21-43.
Additional info: Recognizes the carboxy terminus of human Cbl. Species Crossreactivity: mouse and rat.

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