HCC-1 is a CC chemokine that signals through the CCR1 receptor and chemoattracts blood monocytes. It is secreted by various tissues including skeletal muscle, heart, spleen, liver, bone marrow and plasma. Mature HCC-1 is found in four different forms, which are distinguished by differential N-terminal truncation and contain 74, 72, 71, or 66aa. Recombinant human HCC-1 (66aa) is a 7.8kD protein consisting of 66aa including the four highly conserved residues present in CC chemokines.
Source:
Recombinant protein corresponding to human HCC-1, expressed in E.coli.
Biological Activity:
Determined by its ability to chemoattract human monocytes using a concentration range of 5-20ng/ml.
Endotoxin:
<0.1ng/ug (1EU/ug)
AA Sequence:
GPYHPSECCF TYTTYKIPRQ RIMDYYETNS QCSKPGIVFI TKRGHSVCTN PSDKWVQDYI KDMKEN
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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