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CCR10 (C-C Chemokine Receptor 10, CC-CCR-10, GPR2)

CCR10 (C-C Chemokine Receptor 10, CC-CCR-10, GPR2)

Cat no: C2099-74K

Supplier: United States Biological
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Receptors for the C-C chemokine family include CCR-1, CCR-2A, CCR-3, CCR-4, CCR-5 and the Duffy blood group antigen. The C-C receptors are important in the function of T cell chemotaxis and migration of phagocytic cells to sites of inflammation. CCR10 in particular is the receptor for the skin-associated CC chemokine CCL27 (CTACK) as well as the novel chemokine CCL28 which displays chemotactic activity for resting CD4+ and CD8+ T cells. Cellular Localization: Cell Membrane Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2099-74K
Reactivities: Human
Hosts: Goat
Applications: ELISA, Immunocytochemistry, Immunohistochemistry, Western Blot
Size: 100ug
Form: 10 mM KHPO4, 140 mM NaCl, pH 7.2.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: C-C Chemokine Receptor 10, CC-CCR-10
References: <b>This product has been used in:</b>Wang W <i>et al.</i> Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). <i>J Biol Chem</i> <b>275</b>:22313-23 (2000). <PUBMED:10781587>Zaballos A <i>et al.</i> Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK. <i>J Immunol</i> <b>162</b>:5671-5 (1999). <PUBMED:10229797> 3. Murakami, T., et al. Immune evasion by murine melanoma mediated through CC chemokine receptor-10. J. Exp. Med. 198(9):1337-1347, 2003. 4. Luttichaux IV, et al. Human adult CD34() progenitor cells functionally express the chemokine receptors CCr1, CCR4, CCR7, CXCR5, and CCR10 but not CXCR4. Stem Cell Dev. 14(3):329-336, 2005. 5. Notohamiprodjo, M., et al. CCR10 is expressed in cutaneous T-cell lymphoma. Int. J. Cancer. 115(4): 641-647, 2005. 6. Hirata, T., et al. Human P-selectin glycoprotein ligand-1 (PSGL-1) interacts with the skin-assocaited chemokine CCL27 via sulfated tyrosines at the PSGL-1 amino terminus. J. Biol. Chem. 279(50): 51775-51782, 2004.
Additional info: Peptide sequence is < 50% identical to other human chemokine receptors in this region. Species Crossreactivity: Crossreacts with Human.

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