CD103 is the integrin alphaE subunit which usually forms a heterodimer with the integrin beta7 subunit. It is expressed on intraepithelial lymphocytes and 1-2% of peripheral blood lymphocytes. CD103 binds E-cadherin on epithelial cells. This interaction may be of importance in the homing and retention of CD103+ lymphocytes in the intestinal epithelium.1-4
Applications:
Suitable for use in Flow Cytometry, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Recommended Dilution:
Immunohistochemistry: frozen
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.