CD106 (DKFZp779G2333, INCAM 100, INCAM-100, L1CAM, MGC99561, Vascular Cell Adhesion Molecule 1, VCAM 1, VCAM-1) (FITC)

CD106, otherwise known as VCAM-1 (vascular adhesion molecule 1), is a 110kD inducible type I transmembrane glycoprotein and member of the immunoglobulin supergene family, which is predominantly expressed on vascular endothelium, and also on bone marrow stromal cells, follicular dendritic cells and some macrophages.\n\nCD106 interacts with the lymphocyte homing receptor VLA-4 (alpha4 beta1 integrin) and LPAM-1 (alpha4 beta7 integrin) and mediates leukocyte-endothelial cell adhesion and signal transduction. Expression of CD106 is upregulated following cytokine activation, and endothelial CD106 plays a role in the extravasation of leukocytes from blood vessels during inflammation.\n\nApplications:\nSuitable for use in Flow Cytometry. Other applications not tested.\n\nRecommended Dilution:\nFlow Cytometry: Neat-1:5\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. FITC conjugates are sensitive to light.

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SPECIFICATIONS

Catalog Number

C2446-71L

Size

100ug

Applications

FC

Hosts

Mouse

Reactivities

Rat

Form

Supplied as a liquid in PBS, pH7.4, 0.09% sodium azide, 1% BSA. Labeled with FITC.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG1

References

1. Bevilacqua, M.P. (1993) Endothelial-leukocyte adhesion molecules. Annu. Rev. Immunol. 11 : 767-804.\n2. Kubota, H. et al. (2007) Identification and characterization of vitamin A-storing cells in fetal liver: Implications for functional importance of hepatic stellate cells in liver development and hematopoiesis. Stem Cells. 25: 2339-2349.3. Miyao, N. et al. (2006) Various adhesion molecules impair microvascular leukocyte kinetics in ventilator-induced lung injury. Am. J. Physiol. Lung Cell Mol. Physiol. 290: L1059-L1068.

Additional Info

Recognizes rat CD106 at ~110kD.