VCAM1 is a member of the Ig superfamily and is a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis.
Source:
Recombinant corresponding to aa25-698 from human VCAM1, fused to His-tag at N-terminus, expressed in E.coli.
Molecular Weight:
~76kD (695aa) confirmed by MALDI-TOF
AA Sequence:
MGSSHHHHHH SSGLVPRGSH MFKIETTPES RYLAQIGDSV SLTCSTTGCE SPFFSWRTQI DSPLNGKVTN EGTTSTLTMN PVSFGNEHSY LCTATCESRK LEKGIQVEIY SFPKDPEIHL SGPLEAGKPI TVKCSVADVY PFDRLEIDLL KGDHLMKSQE FLEDADRKSL ETKSLEVTFT PVIEDIGKVL VCRAKLHIDE MDSVPTVRQA VKELQVYISP KNTVISVNPS TKLQEGGSVT MTCSSEGLPA PEIFWSKKLD NGNLQHLSGN ATLTLIAMRM EDSGIYVCEG VNLIGKNRKE VELIVQEKPF TVEISPGPRI AAQIGDSVML TCSVMGCESP SFSWRTQIDS PLSGKVRSEG TNSTLTLSPV SFENEHSYLC TVTCGHKKLE KGIQVELYSF PRDPEIEMSG GLVNGSSVTV SCKVPSVYPL DRLEIELLKG ETILENIEFL EDTDMKSLEN KSLEMTFIPT IEDTGKALVC QAKLHIDDME FEPKQRQSTQ TLYVNVAPRD TTVLVSPSSI LEEGSSVNMT CLSQGFPAPK ILWSRQLPNG ELQPLSENAT LTLISTKMED SGVYLCEGIN QAGRSRKEVE LIIQVTPKDI KLTAFPSESV KEGDTVIISC TCGNVPETWI ILKKKAETGD TVLKSIDGAY TIRKAQLKDA GVYECESKNK VGSQLRSLTL DVQGRENNKD YFSPE
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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