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CD115, Phosphorylated (Tyr723) (Macrophage Colony-stimulating Factor 1 Receptor, CSF-1-R, Proto-oncogene c-Fms, CSF1R, FMS)

CD115, Phosphorylated (Tyr723) (Macrophage Colony-stimulating Factor 1 Receptor, CSF-1-R, Proto-oncogene c-Fms, CSF1R, FMS)

Cat no: C2447-51

Supplier: United States Biological
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Colony-stimulating factor 1(CSF-1) is required for the growth, differentiation and survival of cells of the monocyte/macrophage lineage. CSF-1 binds specific receptor CSF1R, the product of the c-fms gene, leading to receptor dimerization and phosphorylation on tyrosine residue. CSF-1R has been demonstrated as the major regulator of macrophage development as well as great involvement in epithelial cancers, including carcinogenesis of breast, ovary and prostate. CSF- 1R is a tyrosine kinase transmembrane receptor and is one of the members of the CSF1/PDGF receptor family of tyrosine-protein kinases. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:5000-1:20,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2447-51
Reactivities: Human
Hosts: Rabbit
Applications: ELISA
Size: 25ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Novak, U. et al. Blood 86, 2948 (1995) 2. Follows, G.A. et al. EMBO J 22, 2798 (2003). 3. Riccioni, R. et al. Leukemia 17, 98 (2003). 4. Ide, H. et al. Proc Natl Acad Sci USA 99, 14404 (2002). 5. Flick, M.B. et al. J Cell Biochem 85, 10 (2002).
Additional info: Recognizes human CSF-1R when phosphorylated at Tyr723.

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