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CD117 (c-kit, Stem Cell Factor, SCF Receptor, Steel Factor Receptor, Mast Cell Growth Factor, MGF)

Cat no: C2448-02G


Supplier: United States Biological
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Cellular Localization: Type I membrane protein. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2448-02G
Reactivities: Human, Non-Human Primate
Hosts: Mouse
Applications: Flow Cytometry
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
Alternative names: CD117 antigen, C-Kit, Mast/stem cell growth factor receptor precursor, PBT, Proto-oncogene tyrosine-protein kinase Kit, SCFR, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
References: Yoshino N et al. Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies. Exp Anim 49:97-110 (2000). Broudy VC et al. Analysis of c-kit receptor dimerization by fluorescence resonance energy transfer. Blood 91:898-906 (1998).
Additional info: This antibody recognizes the human c-Kit. c-Kit is expressed by some haematopoietic stem cells (approx. 70% of CD34 +ve cells in normal bone marrow are c-Kit +ve), by some acute myeloid leukaemias and by mast cells.This antibody is non-neutralising. Species Crossreactivity: Crossreacts with Human and Cynomolgus Monkey. Not yet tested in other species.

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