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CD119 (Interferon gamma Receptor 1, IFN-gamma Receptor 1, IFN-gamma-R1, CDw119, IFNGR1)

CD119 (Interferon gamma Receptor 1, IFN-gamma Receptor 1, IFN-gamma-R1, CDw119, IFNGR1)

Cat no: C2453-01L

Supplier: United States Biological
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CDw119 is a 90-100kD type I transmembrane protein, also known as IFN-y R a chain or IFN-yRI. The IFN-y receptor is a complex of a high affinity IFN-y-binding chain (aka, IFN-y R a chain) and a second accessory protein required for signal transduction known as IFN-y R B chain. The IFN-y R a chain is a member of the class II cytokine receptor family. Binding of IFN-y induces receptor dimerization and internalization. Signal transduction involves Jak1 and Jak2 protein kinases and involves STAT1 activation. The IFN-y receptor is expressed at moderate levels on virtually every cell with the exception of erythrocytes. Applications: Suitable for use in Immunofluorescence, Flow Cytometry, Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Flow Cytometry: (same/less than)0.5ug/10e5 cells in 100ul Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2453-01L
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunofluorescence, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG2b,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Sheehan, K., et al. 1988. J. Immunol. 140:4231. 2. Jouanguy, E., et al. 2000. J. Clin. Invest. 105:1429. 3. Kaplan, D., et al. 1996. J. Biol. Chem. 271:9. 4. Bach, E. A., et al. 1996. Mol. Cell. Biol. 16:3214. 5. Choi, J. C., et al. 2007. J. Immunol. 178:1598. 6. Humlicek, A.L., et al. 2007. J. Immunol. 178:6395. 7. Calderon, J., et al. 1988. PNAS 85:4837. 8. Basler, C., et al. 2002. Int. Rev. Immunol. 21:305. 9. Brierley, M., et al. 2002. J. Interferon Cytokine Res. 22:835.
Additional info: Recognizes human CD119.

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