Home  >  Products  >  CD11a (CD11 Antigen-like Family Member A, Integrin alpha-L, ITGAL, Leukocyte Adhesion Glycoprotein LFA-1 alpha Chain, Leukocyte Function-associated Molecule 1 alpha Chain, LFA1A, LFA-1A, LFA-1)
CD11a (CD11 Antigen-like Family Member A, Integrin alpha-L, ITGAL, Leukocyte Adhesion Glycoprotein LFA-1 alpha Chain, Leukocyte Function-associated Molecule 1 alpha Chain, LFA1A, LFA-1A, LFA-1)

CD11a (CD11 Antigen-like Family Member A, Integrin alpha-L, ITGAL, Leukocyte Adhesion Glycoprotein LFA-1 alpha Chain, Leukocyte Function-associated Molecule 1 alpha Chain, LFA1A, LFA-1A, LFA-1)

Cat no: C2262-02P

Supplier: United States Biological
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CD11a is expressed on lymphocytes, granulocytes, monocytes and macrophages with increase in levels on memory T cells. CD11a or LFA 1 has a key role in mediating leukocyte adhesion to endothelium during inflammatory responses through binding to ICAM 1 (CD54). Other ligands are ICAM-2 and ICAM-3. It is also involved in many T cell functions and immune phenomena. Mol. weight in SDS gels is about 180kD. Part of heterodimer with CD18 (integrin b2). A defect in b-2 expression results in leukocytes adhesion deficiency (LAD) in which patients suffer from recurring bacterial infections. Applications: Suitable for use in Flow Cytometry and Immunoprecipitation. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2262-02P
Hosts: Mouse
Applications: Flow Cytometry, Immunoprecipitation
Size: 100ug
Form: Supplied as a liquid in PBS, 15mM sodium azide, pH7.4.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein A affinity chromatography.
Alternative names: Integrin alpha L (Antigen CD11A (p180), Lymphocyte Function-associated Antigen 1; alpha Polypeptide)
References: 1. Leucocyte Typing IV, ed. W. Knapp et al., Oxford Univ. Press, Oxford 1989: Workshop nr N205. See also communications: N1.1, N1.4, N1.8 and N1.9. 2. Bazil, V., et al., 1990, Fol. Biol. 36, 41.
Additional info: Recognizes the Lymphocyte Functional Antigen-1 (LFA-1), CD11a, which forms a heterodimer molecule (180-95kD) consisting of the Integrin molecules CD11a and CD18.

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