Home  >  Products  >  CD11a (CD11 Antigen-like Family Member A, Integrin alpha-L, ITGAL, Leukocyte Adhesion Glycoprotein LFA-1 alpha Chain, Leukocyte Function-associated Molecule 1 alpha Chain, LFA1A, LFA-1A, LFA-1)
CD11a (CD11 Antigen-like Family Member A, Integrin alpha-L, ITGAL, Leukocyte Adhesion Glycoprotein LFA-1 alpha Chain, Leukocyte Function-associated Molecule 1 alpha Chain, LFA1A, LFA-1A, LFA-1)

CD11a (CD11 Antigen-like Family Member A, Integrin alpha-L, ITGAL, Leukocyte Adhesion Glycoprotein LFA-1 alpha Chain, Leukocyte Function-associated Molecule 1 alpha Chain, LFA1A, LFA-1A, LFA-1)

Cat no: C2262-02T

Supplier: United States Biological
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CD11a is expressed on lymphocytes, granulocytes, monocytes and macrophages with increase in levels on memory T cells. CD11a or LFA 1 has a key role in mediating leukocyte adhesion to endothelium during inflammatory responses through binding to ICAM 1 (CD54). Other ligands are ICAM-2 and ICAM-3. It is also involved in many T cell functions and immune phenomena. Mol. weight in SDS gels is about 180kD. Part of heterodimer with CD18 (integrin b2). A defect in b-2 expression results in leukocytes adhesion deficiency (LAD) in which patients suffer from recurring bacterial infections. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2262-02T
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry
Size: 100ug
Form: Supplied as liquid in PBS, 15mM sodium azide, pH7.4.
P type: Mab
Isotype: IgG1
Purity: Purified
Alternative names: Integrin alpha L (Antigen CD11A (p180), Lymphocyte Function-associated Antigen 1; alpha Polypeptide)
References: 1. Landis, R.C., et al., 1994, J. Cell Biology 120, 529 (1994) 2. Landis, R.C., et al., 1993, J. Cell Biology 120, 1519-1527. 3. Knapp, W., et al., 1989, Leucocyte Typing IV, Oxford Univ. Press, Workshop nr. N211.
Additional info: Recognizes a unique epitope on CD11a (LFA-1 alpha chain) implicated in activation of LFA-1 complex.

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