Home  >  Products  >  CD11b, Active (Integrin alpha-M, CD11 Antigen-like family Member B, CR-3 alpha Chain, Cell Surface Glycoprotein MAC-1 Subunit alpha, Leukocyte Adhesion Receptor MO1, Neutrophil Adherence Receptor, ITGAM, CR3A)
CD11b, Active (Integrin alpha-M, CD11 Antigen-like family Member B, CR-3 alpha Chain, Cell Surface Glycoprotein MAC-1 Subunit alpha, Leukocyte Adhesion Receptor MO1, Neutrophil Adherence Receptor, ITGAM, CR3A)

CD11b, Active (Integrin alpha-M, CD11 Antigen-like family Member B, CR-3 alpha Chain, Cell Surface Glycoprotein MAC-1 Subunit alpha, Leukocyte Adhesion Receptor MO1, Neutrophil Adherence Receptor, ITGAM, CR3A)

Cat no: C2262-51V

Supplier: United States Biological
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The CBRM1/5 antibody reacts with an activated form of human CD11b, a 165-170kD type I transmembrane glycoprotein also known as aM integrin, Mac-1, CR3, and C3biR. CD11b non-covalently associates with integrin B2 (CD18) and is expressed on granulocytes, monocytes/macrophages dendritic cells, NK cells, and subsets of T and B cells. CD11b/CD18 is critical for the transendothelial migration of monocytes and neutrophils, as well as adhesion, phagocytosis and neutrophil activation. CD11b/CD18 interacts with ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen and Factor X. The CBRM1/5 antibody recognizes a subset of CD11b molecules on neutrophils and monocytes activated with chemoattractants or phorbol-esters. This antibody does not recognize "non-activated" CD11b. The epitope recognized by CBRM1/5 is contained in the I domain of the a chain. This antibody blocks cell adhesion to fibrinogen and ICAM-1. Applications: Suitable for use in Immunoprecipitation, Flow Cytometry and Blocking of the Binding of ICAM-1 and Fibrinogen. Other applications not tested. Recommended Dilution: Flow Cytometry: (same/less than)2ug/10e5 cells in 100ul Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2262-51V
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunoprecipitation
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Diamond, M., et al. 1993. J. Cell Biol. 120:545. 2. Bryn, T., et al. 2006. J. Immunol. 176: 7361.J Immunol 3. Sithu, S.D., et al. 2007. J. Biol. Chem. doi:10.1074/jbc.M611273200. 4. Barthel, SR.,et al.2006. Am J. Respir Cell Mol Biol.35:378. 5. Pillay, J.,et al. 2010. J. Leukoc Biol. 88:211. 6. Stewart, M., et al. 1995. Curr. Opin. Cell Biol. 7:690. 7. Petty, H., et al. 1996. Immunol. Today 17:209.
Additional info: Recognizes the activated form of human CD11b.

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