ITGAX gene encodes the integrin alpha X chain protein. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. This protein has an extracellular domain of 1,081 amino acids containing 10 potential glycosylation sites, a transmembrane domain of 26 amino acids, and a C-terminal cytoplasmic tail of 29 residues. It shows homology to the alpha subunits of platelet glycoprotein IIb/IIIa, vitronectin receptor, and fibronectin receptor. The receptors involved in both cell-cell and cell-matrix interactions appear to belong to a single superfamily of genes termed the integrins. It localizes in the 16p11.2. The ITGAX has been reported in B-cell, blood, blood vessel, bone marrow, leucocyte, liver, spleen and uterus.
Applications:
Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilution:
Immunohistochemistry (paraffin): 20ug/ml
Optimal dilutions to be determined by the researcher.
Positive Control:
Colon, neutrophils
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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