Home  >  Products  >  CD11c (Integrin alpha-X, CD11 Antigen-like Family Member C, Leu M5, Leukocyte Adhesion Glycoprotein p150,95 alpha Chain, Leukocyte Adhesion Receptor p150,95, ITGAX)
CD11c (Integrin alpha-X, CD11 Antigen-like Family Member C, Leu M5, Leukocyte Adhesion Glycoprotein p150,95 alpha Chain, Leukocyte Adhesion Receptor p150,95, ITGAX)

CD11c (Integrin alpha-X, CD11 Antigen-like Family Member C, Leu M5, Leukocyte Adhesion Glycoprotein p150,95 alpha Chain, Leukocyte Adhesion Receptor p150,95, ITGAX)

Cat no: C2262-65Q

Supplier: United States Biological
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CD11c is a 145-150kD type I transmembrane glycoprotein also known as integrin alphaX and CR4. CD11c non-covalently associates with integrin B2 (CD18) and is expressed on monocytes/macrophages, dendritic cells, granulocytes, NK cells, and subsets of T and B cells. CD11c has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b. This antibody preferentially binds the activated form of CD11c, is specific for I domain of CD11c, and is able to partially block the binding of CD11c and ICAM-4. Binding is divalent cation dependent. Applications: Suitable for use in Flow Cytometry and Immunohistochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: (same/less than)2ug/10e5 cells in 100ul Immunohistochemistry: acetone-fixed, frozen tissue sections Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2262-65Q
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Schlossman, S., et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York. 2. Knapp, W., et al. 1989. Leucocyte Typing IV, Oxford University Press. New York. 3. McMichael, A., et al. Eds. 1987. Leucocyte Typing III, Oxford University Press. New York. 4. Vainer, B., et al. 2000. Am. J. Surg. Pathol. 24:1115. 5. Ottonello, L., et al. 1999. Blood 93:3505. 6. Metelitsa, L.S., et al. 2002. Blood 99:4166. 7. Sadhu, C., et al. 2007. J. Leukoc. Biol. doi:10.1189/jlb.1106680. 8. Ihanus E., et al. 2007. Blood 109:802-810. 9. Gurer, C., et al. 2008. Blood 112:1231. 10. Asai, A., et al. 2009. J. Lipid Res. 50:95. 11. Yoshino, N., et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC) 12. Petty, H. 1996. Immunol. Today 17:209. 13. Springer, T. 1994. Cell 76:301. 14. Ihanus E., et al. 2007. Blood. 109:802-810.
Additional info: Recognizes human CD11c. Species Crossreactivity: cynomolgus, rhesus.

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