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CD120a TNF-R1 Antibody

CD120a TNF-R1 Antibody

Cat no: 251904

Supplier: ABBIOTEC
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Tumor necrosis factor receptor superfamily member 1A (CD120a TNF-R1) is a receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphoto, Xenopus/Amphibian,in-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling comple, Xenopus/Amphibian, (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. CD120a TNF-R1contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Defects in TNFRSF1A are the cause of familial hibernian fever (FHF) also known as tumor necrosis factor receptor-associated periodic syndrome (TRAPS). FHF is a hereditary periodic fever syndrome characterized by recurrent fever, abdominal pain, localized tender skin lesions and myalgia. Reactive amyloidosis is the main complication and occurs in 25% of cases.
Catalogue number: 251904
Reactivities: Human
Applications: Immunohistochemistry
Size: 0.1 mg
Accession: P19438
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human CD120a TNF-R1.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.1%BSA with 0.09% sodium azide. Antibody was purified by immunogen-affinity chromatography.
P type: Rabbit Polyclonal Antibody
Isotype: Rabbit Ig
Additional info: Tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor 1; TNF-R1; Tumor necrosis factor receptor type I; TNF-RI; TNFR-I; p60; p55; CD120a; TNFRSF1A; TNFAR; TNFR1
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