Home  >  Products  >  CD122 (CD122 Antigen, High Affinity IL-2 Receptor beta Subunit, Interleukin 2 Receptor beta, Interleukin 2 Receptor Subunit beta, IL-2 Receptor, IL-2RB, IL2RB, OTTHUMP00000028799, P70-75, p75)
CD122 (CD122 Antigen, High Affinity IL-2 Receptor beta Subunit, Interleukin 2 Receptor beta, Interleukin 2 Receptor Subunit beta, IL-2 Receptor, IL-2RB, IL2RB, OTTHUMP00000028799, P70-75, p75)

CD122 (CD122 Antigen, High Affinity IL-2 Receptor beta Subunit, Interleukin 2 Receptor beta, Interleukin 2 Receptor Subunit beta, IL-2 Receptor, IL-2RB, IL2RB, OTTHUMP00000028799, P70-75, p75)

Cat no: C2460-01M

Supplier: United States Biological
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IL-2 is a T cell stimulatory cytokine best known for inducing T cell proliferation and NK cell proliferation and activation (1,2). IL-2 also promotes peripheral development of Treg cells (4,5). Conversely, IL-2 is involved in activation induced cell death (AICD) that is observed post T cell expansion by increasing levels of Fas on CD4+ T cells (3). The effects of IL-2 are mediated through a trimeric receptor complex consisting of IL-2Ra, IL-2RB and the common gamma chain, gc (1,2). IL-2Ra binds exclusively to IL-2 with low affinity and increases binding affinity of the whole receptor complex including IL-2RB and gc subunits. IL-15 also binds to IL-2RB (1,2). The common gc is used by other cytokines including IL-4, IL-7, IL-9, IL-15, and IL-21(1,2). Binding of IL-2 initiates signaling cascades involving Jak1, Jak3, Stat5 and the PI3K/Akt pathways (1,2). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000. Incubate membrane with diluted antibody in 5% w/v BSA, 1X TBS, 0.1% Tween-20 at 4 degrees C with gentle shaking, overnight. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2460-01M
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied in 10mM sodium HEPES pH 7.5, 150mM NaCl, 0.1mg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
P type: Pab
Purity: Purified by Protein A affinity chromatography.
References: 1. Ma, A. et al. (2006) Annu Rev Immunol 24, 657-79, 2. Gaffen, S.L. and Liu, K.D. (2004) Cytokine 28, 109-23, 3. Jaleco, S. et al. (2003) J Immunol 171, 61-8, 4. Fehe?rvari, Z. et al. (2006) Trends Immunol 27, 109-11, 5. Antony, P.A. et al. (2006) J Immunol 176, 5255-66.
Additional info: Recognizes human IL-2RB.

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