Home  >  Products  >  CD13 (Alanyl Aminopeptidase, Alanyl Membrane Aminopeptidase, Aminopeptidase M, gp150, Aminopeptidase N, ANPEP, APN, CD13 Antigen, hAPN, Lap 1, Lap1, Microsomal Aminopeptidase, Myeloid Plasma Membrane Glycoprotein CD13, p150, PEPN)
CD13 (Alanyl Aminopeptidase, Alanyl Membrane Aminopeptidase, Aminopeptidase M, gp150, Aminopeptidase N, ANPEP, APN, CD13 Antigen, hAPN, Lap 1, Lap1, Microsomal Aminopeptidase, Myeloid Plasma Membrane Glycoprotein CD13, p150, PEPN)

CD13 (Alanyl Aminopeptidase, Alanyl Membrane Aminopeptidase, Aminopeptidase M, gp150, Aminopeptidase N, ANPEP, APN, CD13 Antigen, hAPN, Lap 1, Lap1, Microsomal Aminopeptidase, Myeloid Plasma Membrane Glycoprotein CD13, p150, PEPN)

Cat no: C2264-03C

Supplier: United States Biological
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The murine homolog of human CD13 is a 160kD cell surface antigen with aminopeptidase N activity. In steady state mice, the CD13 antigen is expressed primarily by dendritic cell and mature macrophage subpopulations. The level of CD13 antigen expression increases with maturation, after the monocytic stage. Bone marrow cells and peripheral blood monocytes are reported to be CD13 negative while thioglycollate-elicited macrophages express high levels of CD13. Dendritic cells, interdigitating dendritic cells, veiled cells and Langerhans cells all express CD13, which is reported to be involved in the development of immature dendritic cells from monocytes. Applications: Suitable for use in Flow Cytometry and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Flow Cytometry: 1:10-1:50; 10ul labels 10e6 cells in 100ul Immunohistochemistry: Frozen sections Optimal dilutions to be determined by the researcher. Hybridoma: Y3-Ag1.2.3 rat myeloma cells with spleen cells from immunized rats. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2264-03C
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry, Immunohistochemistry
Size: 250ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein G affinity chromatography.
References: 1. Leenen, P.J.M. et al. (1992) The monoclonal antibody ER-BMDM1 recognizes a macrophage and dendritic cell differentiation antigen with aminopeptidase activity. Eur. J. Immunol. 22:1567-1572. 2. Leenen, P. et al. (1998) Heterogeneity of mouse spleen dendritic cells: in vivo phagocytic activity, expression of macrophage markers, and subpopulation turnover. J Immunol. 160:2166-73. 3. Sen, A. et al. (2012) Innate immune response to homologous rotavirus infection in the small intestinal villous epithelium at single-cell resolution. Proc Natl Acad Sci Nov 27
Additional info: Recognizes the murine homolog of human CD13.

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